Upstream / Downstream


Explore pathways related to this product.


Find answers on our FAQs page.


PhosphoSitePlus® Resource

  • Additional protein information
  • Analytical tools


We recommend the following alternatives

W IP         H M R Mk
29 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

ANT2/SLC25A5 Antibody recognizes endogenous levels of total ANT2/SLC25A5 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly158 of human ANT2/SLC25A5 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Adenine nucleotide translocase 2 (ANT2/SLC25A5) is a member of the adenine nucleotide translocase family of mitochondrial inner membrane proteins that function differently in metabolic and apoptotic pathways (1). Research studies indicate that ANT2 expression in undifferentiated, proliferating cells correlates with the rate of glycolytic metabolism and may be an indicator of carcinogenesis (2). Suppression of ANT2/SLC25A5 expression by specific RNA interference in human breast cancer cells promotes apoptosis and inhibits tumor cell growth (2), which suggests a cytoprotective role of ANT2/SLC25A5 (1,3).

1.  Brenner, C. et al. (2011) Oncogene 30, 883-95.

2.  Chevrollier, A. et al. (2011) Biochim Biophys Acta 1807, 562-7.

3.  Jang, J.Y. et al. (2008) Breast Cancer Res 10, R11.

Entrez-Gene Id 292
Swiss-Prot Acc. P05141

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

ANT2/SLC25A5 Antibody