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Lmx1B Antibody

Lmx1B Antibody #12607

This product is discontinued

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Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Lmx1B Antibody recognizes transfected levels of total Lmx1B protein.

Species predicted to react based on 100% sequence homology:

Mouse, Rat, Monkey

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly210 of human Lmx1B protein. Antibodies are purified by protein A and peptide affinity chromatography.

LIM homeobox transcription factor 1 β (Lmx1B) is a member of an evolutionarily conserved family of transcription factors that regulate developmental pattern formation in both vertebrates and invertebrates (1). Numerous developmental studies show that Lmx1B is required for vertebrate dorsoventral limb patterning, as well as normal glomerular basement membrane development and typical differentiation of central serotonergic neurons (2,3).

Mutations in the corresponding Lmx1B gene have been associated with nail-patella syndrome (NPS), an autosomal dominant disorder characterized by dysplasia of fingernails, skeletal anomalies and, frequently, renal disease (2). Abnormal developmental disorders such as developmental glaucoma and idiopathic Parkinson’s disease have also been associated with Lmx1B function (4,5).

  1. Hobert, O. and Westphal, H. (2000) Trends Genet 16, 75-83.
  2. Dai, J.X. et al. (2009) Dev Growth Differ 51, 241-50.
  3. Yan, C.H. et al. (2011) J Neurosci 31, 12413-25.
  4. Gould, D.B. et al. (2004) Int J Dev Biol 48, 1015-29.
  5. Ramsden, D.B. et al. (2001) Mol Pathol 54, 369-80.
Entrez-Gene Id
Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

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