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50 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

SHMT1 Antibody recognizes endogenous levels of total SHMT1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human SHMT1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Serine hydroxymethyltransferases 1 and 2 (SHMT1, SHMT2) are cytoplasmic and mitochondrial serine hydroxylmethyltransferases, respectively (1,2). They catalyze the conversion of serine to glycine with the transfer of β-carbon from serine to tetrahydrofolate (THF) to form 5, 10-methylene-THF (1, 2). Research studies indicate that SHMT1 hemizygosity is associated with higher risk of intestinal cancer in mice of a certain genetic background (3). Suppression of SHMT2 was shown to block cell proliferation (4).

1.  MacFarlane, A.J. et al. (2008) J Biol Chem 283, 25846-53.

2.  Hebbring, S.J. et al. (2012) J Neurochem 120, 881-90.

3.  Macfarlane, A.J. et al. (2011) Cancer Res 71, 2098-107.

4.  di Salvo, M.L. et al. (2013) Med Hypotheses 80, 633-6.

Entrez-Gene Id 6470
Swiss-Prot Acc. P34896

For Research Use Only. Not For Use In Diagnostic Procedures.
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SHMT1 Antibody