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142 Mouse 

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

DSG2 (10D2) Mouse mAb (IF Specific) recognizes endogenous levels of total DSG2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the amino terminus of human DSG2 protein.

Desmosomes are a class of intracellular junction that tightly link adjacent cells in mechanically stressed tissues such as the epithelium and myocardium (1). They derive their characteristic strength from the protein desmoplakin, which acts as a tether by binding the cytoplasmic component of the desmosome at its N terminus (2), while its C terminus is anchored to the intermediate-filament cytoskeleton (3). Desmogleins and desmocollins belong to the superfamily of cadherin proteins, the "glue" of the desmosome, as they are essential for strong cell-cell contacts (4). There are 4 types of desmogleins in humans, DSG1-4, and 3 types of desmocollins, DSC1-3. DSG2 is expressed in all desmosome bearing tissues, while other desmosome cadherin proteins have more specialized tissue expression. Research studies have shown that aberrant expression due to mutation of DSG2 is associated with arrhythmogenic right ventricular cardiomyopathy (5,6). Research has also shown that mutation and altered expression of DSG1 and 3 have been associated with autoimmune disorders such as Pemphigus, inherited disorders such as defective hair-follicle differentiation, and striate palmoplantar keratoderma, an epidermal-thickening disease (reviewed in 7).

1.  Stokes, D.L. (2007) Curr Opin Cell Biol 19, 565-71.

2.  Kowalczyk, A.P. et al. (1997) J Cell Biol 139, 773-84.

3.  Meng, J.J. et al. (1997) J Biol Chem 272, 21495-503.

4.  Nollet, F. et al. (2000) J Mol Biol 299, 551-72.

5.  Awad, M.M. et al. (2006) Am J Hum Genet 79, 136-42.

6.  Pilichou, K. et al. (2006) Circulation 113, 1171-9.

7.  Delva, E. et al. (2009) Cold Spring Harb Perspect Biol 1, a002543.

Entrez-Gene Id 1829
Swiss-Prot Acc. Q14126

For Research Use Only. Not For Use In Diagnostic Procedures.
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DSG2 (10D2) Mouse mAb (IF Specific)