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- Analytical tools
DSG2 (10D2) Mouse mAb (IF Specific) #12631
This product is discontinued
Gallery: DSG2 (10D2) Mouse mAb (IF Specific) #12631
DSG2 (10D2) Mouse mAb (IF Specific) recognizes endogenous levels of total DSG2 protein.
Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the amino terminus of human DSG2 protein.
Desmosomes are a class of intracellular junction that tightly link adjacent cells in mechanically stressed tissues such as the epithelium and myocardium (1). They derive their characteristic strength from the protein desmoplakin, which acts as a tether by binding the cytoplasmic component of the desmosome at its N terminus (2), while its C terminus is anchored to the intermediate-filament cytoskeleton (3). Desmogleins and desmocollins belong to the superfamily of cadherin proteins, the "glue" of the desmosome, as they are essential for strong cell-cell contacts (4). There are 4 types of desmogleins in humans, DSG1-4, and 3 types of desmocollins, DSC1-3. DSG2 is expressed in all desmosome bearing tissues, while other desmosome cadherin proteins have more specialized tissue expression. Research studies have shown that aberrant expression due to mutation of DSG2 is associated with arrhythmogenic right ventricular cardiomyopathy (5,6). Research has also shown that mutation and altered expression of DSG1 and 3 have been associated with autoimmune disorders such as Pemphigus, inherited disorders such as defective hair-follicle differentiation, and striate palmoplantar keratoderma, an epidermal-thickening disease (reviewed in 7).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc. DRAQ5 is a registered trademark of Biostatus Limited.