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130 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

BACH2 Antibody recognizes endogenous levels of total BACH2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala304 of human BACH2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

The transcription regulator BTB and CNC homolog 2 (BACH2) is a bZIP domain-containing transcriptional repressor that dimerizes with MafK and binds Maf recognition elements (MAREs) to regulate transcription (1,2). BACH2 is part of a network of transcription factors that controls the transition of activated B cells into either antibody-producing plasma cells or memory B cells (3-5). Plasma cell differentiation requires the transcription factor Blimp1 (6). BACH2 suppresses expression of Blimp1 in activated B cells, which delays plasma cell differentiation and allows time for class switch recombination and somatic hypermutation (3-5). Genome-wide association studies have linked the genetic locus containing BACH2 to several immune-related disorders including type 1 diabetes, celiac disease, Crohn’s disease, and the skin condition known as vitiligo (7-10).

1.  Oyake, T. et al. (1996) Mol Cell Biol 16, 6083-95.

2.  Muto, A. et al. (1998) EMBO J 17, 5734-43.

3.  Muto, A. et al. (2004) Nature 429, 566-71.

4.  Ochiai, K. et al. (2006) J Biol Chem 281, 38226-34.

5.  Muto, A. et al. (2010) EMBO J 29, 4048-61.

6.  Shaffer, A.L. et al. (2002) Immunity 17, 51-62.

7.  Cooper, J.D. et al. (2008) Nat Genet 40, 1399-401.

8.  Dubois, P.C. et al. (2010) Nat Genet 42, 295-302.

9.  Franke, A. et al. (2010) Nat Genet 42, 1118-25.

10.  Jin, Y. et al. (2012) Nat Genet 44, 676-80.

Entrez-Gene Id 60468
Swiss-Prot Acc. Q9BYV9

For Research Use Only. Not For Use In Diagnostic Procedures.
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BACH2 Antibody