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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

IGF-II Receptor/CI-M6PR Antibody recognizes endogenous levels of total IGF-II receptor (CI-M6PR).

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala1675 of human IGF-II receptor (CI-M6PR). Antibodies are purified by protein A and peptide affinity chromatography.

Insulin-like growth factor II (IGF-II) receptor, also widely known as cation-independent mannose 6-phosphate receptor (CI-M6PR), is a multifunctional type I transmembrane glycoprotein that participates in the internalization of mannose-6-phosphate modified hydrolases and IGF-II from the plasma membrane (1,2). In the absence of ligands, IGF-II receptor is constitutively endocytosed from the cell surface to accumulate in the Golgi apparatus (3). In the presence of ligands, the receptor transports the mannose-6-phosphate modified hydrolases to acidified endosomes and lysosomes (4). The ligand-free receptor is then transported back to the Golgi compartment or the cell surface (4). In several research studies, IGF-II receptor has been recognized as a tumor suppressor in a number of cancers (5-7).

1.  Lobel, P. et al. (1989) Cell 57, 787-96.

2.  Kiess, W. et al. (1988) J Biol Chem 263, 9339-44.

3.  York, S.J. et al. (1999) J Biol Chem 274, 1164-71.

4.  Duncan, J.R. and Kornfeld, S. (1988) J Cell Biol 106, 617-28.

5.  Oates, A.J. et al. (1998) Breast Cancer Res Treat 47, 269-81.

6.  Martin-Kleiner, I. and Gall Troselj, K. (2010) Cancer Lett 289, 11-22.

7.  Puxbaum, V. et al. (2012) J Hepatol 57, 337-43.

Entrez-Gene Id 3482
Swiss-Prot Acc. P11717

For Research Use Only. Not For Use In Diagnostic Procedures.
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IGF-II Receptor/CI-M6PR Antibody