Upstream / Downstream


Explore pathways related to this product.

Our U.S. Offices Are Closed

Our U.S. offices are closed in observance of Memorial Day. We will reopen on Tuesday, May 30th.

Thank you for your patience.


Find answers on our FAQs page.


PhosphoSitePlus® Resource

  • Additional protein information
  • Analytical tools


We recommend the following alternatives

W IP   IF     H M R Mk
275 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

IGF-II Receptor/CI-M6PR Antibody recognizes endogenous levels of total IGF-II receptor (CI-M6PR).

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala1675 of human IGF-II receptor (CI-M6PR). Antibodies are purified by protein A and peptide affinity chromatography.

Insulin-like growth factor II (IGF-II) receptor, also widely known as cation-independent mannose 6-phosphate receptor (CI-M6PR), is a multifunctional type I transmembrane glycoprotein that participates in the internalization of mannose-6-phosphate modified hydrolases and IGF-II from the plasma membrane (1,2). In the absence of ligands, IGF-II receptor is constitutively endocytosed from the cell surface to accumulate in the Golgi apparatus (3). In the presence of ligands, the receptor transports the mannose-6-phosphate modified hydrolases to acidified endosomes and lysosomes (4). The ligand-free receptor is then transported back to the Golgi compartment or the cell surface (4). In several research studies, IGF-II receptor has been recognized as a tumor suppressor in a number of cancers (5-7).

1.  Lobel, P. et al. (1989) Cell 57, 787-96.

2.  Kiess, W. et al. (1988) J Biol Chem 263, 9339-44.

3.  York, S.J. et al. (1999) J Biol Chem 274, 1164-71.

4.  Duncan, J.R. and Kornfeld, S. (1988) J Cell Biol 106, 617-28.

5.  Oates, A.J. et al. (1998) Breast Cancer Res Treat 47, 269-81.

6.  Martin-Kleiner, I. and Gall Troselj, K. (2010) Cancer Lett 289, 11-22.

7.  Puxbaum, V. et al. (2012) J Hepatol 57, 337-43.

Entrez-Gene Id 3482
Swiss-Prot Acc. P11717

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

IGF-II Receptor/CI-M6PR Antibody