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12925
SYVN1 Antibody

SYVN1 Antibody #12925

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
  • IF
H Mk
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

SYVN1 Antibody recognizes endogenous levels of total synoviolin-1 protein. This antibody does not cross-react with AMFR/gp78.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human synoviolin-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Synoviolin-1 (SYVN1/HRD1) is a RING-type E3 ubiquitin-protein ligase and major component of the endoplasmic reticulum (ER) quality control system that is involved in the ubiquitin-dependent degradation of misfolded proteins (1). SYVN1 is a multispanning ER membrane protein whose expression is upregulated at the protein level under conditions that promote ER stress (1-4). Research studies have shown that SYVN1 is an anti-apoptotic factor that is implicated in the pathogenesis of arthropathy by promoting synovial hyperplasia (5). Furthermore, gene-targeting studies have demonstrated that SYVN1 expression is indispensable for embryogenesis (6).

  1. Kikkert, M. et al. (2004) J Biol Chem 279, 3525-34.
  2. Kaneko, M. et al. (2007) FEBS Lett 581, 5355-60.
  3. Yamamoto, K. et al. (2008) J Biochem 144, 477-86.
  4. Nadav, E. et al. (2003) Biochem Biophys Res Commun 303, 91-7.
  5. Amano, T. et al. (2003) Genes Dev 17, 2436-49.
  6. Yagishita, N. et al. (2005) J Biol Chem 280, 7909-16.
Entrez-Gene Id
84447
Swiss-Prot Acc.
Q86TM6
For Research Use Only. Not For Use In Diagnostic Procedures.

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