Upstream / Downstream


Explore pathways related to this product.


Find answers on our FAQs page.


PhosphoSitePlus® Resource

  • Additional protein information
  • Analytical tools


We recommend the following alternatives

W IP   IF     H
82 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Mitofusin-1 Antibody recognizes endogenous levels of total mitofusin-1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human mitofusin-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Mitofusins are mitochondrial transmembrane GTPases that function to regulate mitochondrial fusion, a process that occurs in concert with mitochondrial division and is necessary for the maintenance of structural and genetic mitochondrial integrity (1,2). Two mitofusins have been described in mammals, mitofusin-1 and -2, which share 60% amino acid identity and appear to function coordinately to regulate mitochondrial fusion (3). Mitochondrial fusion is widely recognized as important for normal cell growth and development (4), and may have evolved as a mechanism to offset the deleterious effects of mtDNA mutations (3). Null mutations in either mitofusin are embryonic lethal in mice, whereas conditional knockout studies have shown that combined deletion of mitofusin-1 and mitofusin-2 in skeletal muscle results in severe mitochondrial dysfunction (3).

1.  Zhang, Y. and Chan, D.C. (2007) FEBS Lett 581, 2168-73.

2.  Chan, D.C. (2006) Annu Rev Cell Dev Biol 22, 79-99.

3.  Chen, H. et al. (2010) Cell 141, 280-9.

4.  Bereiter-Hahn, J. and Vöth, M. (1994) Microsc Res Tech 27, 198-219.

Entrez-Gene Id 55669
Swiss-Prot Acc. Q8IWA4

For Research Use Only. Not For Use In Diagnostic Procedures.
SignalSilence is a registered trademark of Cell Signaling Technology, Inc.

Mitofusin-1 Antibody