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PhosphoSitePlus® Resource

  • Additional protein information
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140 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

LATS2 Antibody recognizes endogenous levels of total LATS2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LATS2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Large tumor suppressor kinase 2 (LATS2) is an AGC kinase of the NDR family of kinases. It is a LATS family tumor suppressor that plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability (1). LATS2 inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity (2). It also plays an important role in regulation of the Hippo pathway, which is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis (3-5).

1.  Yabuta, N. et al. (2007) J Biol Chem 282, 19259-71.

2.  Li, Y. et al. (2003) Oncogene 22, 4398-405.

3.  Harvey, K. and Tapon, N. (2007) Nat Rev Cancer 7, 182-91.

4.  Zeng, Q. and Hong, W. (2008) Cancer Cell 13, 188-92.

5.  Visser, S. and Yang, X. (2010) Cell Cycle 9, 3892-903.

Entrez-Gene Id 26524
Swiss-Prot Acc. Q9NRM7

For Research Use Only. Not For Use In Diagnostic Procedures.
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LATS2 Antibody