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2660
Emerin (A212) Antibody

Emerin (A212) Antibody #2660

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
H
  • WB
  • IP
H
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Emerin (A212) Antibody detects endogenous levels of total Emerin protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala212 of human Emerin. Antibodies are purified by peptide affinity chromatography.

Emerin is a broadly expressed integral protein of the nuclear inner membrane (1). It contains a LEM domain and binds to several nuclear proteins, such as BAF (barrier-to-autointegration factor) and A- and B-type lamins, which are important in nuclear functions (2-5). Emerin may regulate gene expression through binding to other transcriptional regulators (6,7). Emerin binds to β-catenin and inhibits its nuclear accumulation (8). Recent studies demonstrate that emerin is required for HIV-1 infectivity (9). Mutations in the gene encoding emerin (EMD) are a major cause of Emery-Dreifuss muscular dystrophy (EDMD), a disorder characterized by progressive skeletal muscle weakening (10).

  1. Nagano, A. et al. (1996) Nat. Genet. 12, 254-259.
  2. Manilal, S. et al. (1998) Biochem. Biophys. Res. Commun. 249, 643-647.
  3. Clements, L. et al. (2000) Biochem. Biophys. Res. Commun. 267, 709-714.
  4. Lee, K.K. et al. (2001) J. Cell Sci. 114, 4567-4573.
  5. Bengtsson, L. and Wilson, K.L. (2006) Mol. Biol. Cell 17, 1154-1163.
  6. Holaska, J.M. et al. (2003) J. Biol. Chem. 278, 6969-6975.
  7. Haraguchi, T. et al. (2004) Eur. J. Biochem. 271, 1035-1045.
  8. Markiewicz, E. et al. (2006) EMBO J. 25, 3275-3285.
  9. Jacque, J.M. and Stevenson, M. (2006) Nature 441, 641-645.
  10. Holaska, J.M. and Wilson, K.L. (2006) Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 288, 676-680.
Entrez-Gene Id
2010
Swiss-Prot Acc.
P50402
For Research Use Only. Not For Use In Diagnostic Procedures.

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