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75-120 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

4F2hc/CD98 Antibody recognizes endogenous levels of total 4F2hc/CD98 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg524 of human 4F2hc/CD98 protein. Antibodies are purified by protein A and peptide affinity chromatography.

4F2hc is a transmembrane protein that belongs to the solute carrier family. 4F2hc forms heterodimeric complexes with various amino acid transporters such as LAT1 and LAT2 and regulates uptake of amino acids (1-5). 4F2hc is one of the earliest expressed antigens on the surface of activated human lymphocytes (6), hence it is also named CD98. 4F2hc is expressed in all cell types with the exception of platelets, and is expressed at highest levels in the tubules of the kidney and the gastrointestinal tract (7,8). It is localized at the plasma membrane when associated with LAT1 or LAT2 (9) and at the apical membrane of placenta (10). Research studies have shown that 4F2hc is highly expressed in various tumors including glioma (11), ovarian cancer (12), and astrocytomas (13), and it has been implicated in tumor progression and correlated with poor outcome in patients with pulmonary neuroendocrine tumors (14). 4F2hc is also involved in integrin trafficking through association with β1 and β4 integrins, and regulates keratinocyte adhesion and differentiation (15).

1.  Kanai, Y. et al. (1998) J Biol Chem 273, 23629-32.

2.  Mastroberardino, L. et al. (1998) Nature 395, 288-91.

3.  Pfeiffer, R. et al. (1999) EMBO J 18, 49-57.

4.  Pineda, M. et al. (1999) J Biol Chem 274, 19738-44.

5.  Sato, H. et al. (1999) J Biol Chem 274, 11455-8.

6.  Lumadue, J.A. et al. (1987) Proc Natl Acad Sci USA 84, 9204-8.

7.  Rossier, G. et al. (1999) J Biol Chem 274, 34948-54.

8.  Dave, M.H. et al. (2004) J Physiol 558, 597-610.

9.  Bröer, A. et al. (2001) Biochem J 355, 725-31.

10.  Ritchie, J.W. and Taylor, P.M. (2001) Biochem J 356, 719-25.

11.  Okubo, S. et al. (2010) J Neurooncol 99, 217-25.

12.  Kaji, M. et al. (2010) Int J Gynecol Cancer 20, 329-36.

13.  Nawashiro, H. et al. (2006) Int J Cancer 119, 484-92.

14.  Kaira, K. et al. (2011) Oncol Rep 26, 931-7.

15.  Lemaître, G. et al. (2011) J Dermatol Sci 61, 169-79.

Entrez-Gene Id 6520
Swiss-Prot Acc. P08195

For Research Use Only. Not For Use In Diagnostic Procedures.
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4F2hc/CD98 Antibody