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- Analytical tools
Trf1 (BED5) Mouse mAb #3529
This product is discontinued
Gallery: Trf1 (BED5) Mouse mAb #3529
Trf1 (BED5) Mouse mAb detects endogenous levels of total Trf1 protein.
Monoclonal antibody is produced by immunizing animals with recombinant human Trf1.
Telomeres, the linear ends of chromosomes, are organized into T-loops to prevent them from being recognized by the cell as DNA double stranded breaks (DSBs) (1). A large number of proteins, including telomeric repeat binding factor proteins Trf1 and Trf2, are bound to the telomeres forming a complex of proteins known as shelterin or the telosome (2). Both Trf1 and Trf2 are known to regulate telomere length, participate in the DNA damage response, and contribute to chromosome stability (3-5).
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