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Phospho-Pin1 (Ser16) Antibody

Phospho-Pin1 (Ser16) Antibody #3721

This product is discontinued


Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Phospho-Pin1 (Ser16) Antibody detects endogenous levels of Pin1 only when phosphorylated at serine 16.

Species predicted to react based on 100% sequence homology:

Human, Mouse, Xenopus

Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser16 of human Pin1. Antibodies are purified by protein A and peptide affinity chromatography.

Pin1, a member of the parvulin family of peptidyl-prolyl isomerases (PPIase), has been implicated in the G2/M transition of the mammalian cell cycle (1-6). Pin1 is a small (18 kDa) protein with two distinct functional domains: an amino-terminal WW domain and a carboxy-terminal PPlase domain. Pin1 interacts with several mitotic phosphoproteins, including Plk1, cdc25C and cdc27, and is thought to act as a phosphorylation-dependent PPlase for these target molecules (7-9).

Phosphorylation of pin1 at Ser16 affects its subcellular localization and the ability of its WW domain to interact with potential targets (10).

  1. Lu, P.J. et al. (1999) Science 283, 1325-8.
  2. Verdecia, M. A. et al. (2000) Nat. Struct. Biol. 7, 639-643.
  3. Lu, K. P. et al. (1996) Nature 380, 544-547.
  4. Zhou, X. Z. et al. (2000) Mol. Cell 6, 873-883.
  5. Wu, X. et al. (2000) EMBO J. 19, 3727-3738.
  6. Winkler, K. E. et al. (2000) Science 287, 1644-1647.
  7. Crenshaw, D. G. et al. (1998) EMBO J. 17, 1315-1327.
  8. Shen, M. et al. (1998) Genes Dev. 12, 706-720.
  9. Yaffe, M.B. et al. (1997) Science 278, 1957-60.
  10. Lu, P. J. et al. (2002) J Biol Chem 277, 2381-2384.
Entrez-Gene Id
Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

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