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- Analytical tools
Rheb Antibody #4935
This product is discontinued
Gallery: Rheb Antibody #4935
Rheb Antibody detects endogenous levels of Rheb. The antibody does not cross-react with other family members at physiological levels.Species predicted to react based on 100% sequence homology: Bovine
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn50 of Rheb. Antibodies are purified by protein A and peptide affinity chromatography.
Ras Homolog Enriched in Brain (Rheb) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure (1). While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Like other Ras family members, Rheb triggers activation of the Raf-MEK-MAPK pathway (2). Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/TOR signaling pathway (3-6). The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with translation and cell growth. The tuberin/hamartin (TSC2/TSC1) complex inhibits mTOR activity indirectly by inhibiting Rheb through the tuberin GAP activity (7).
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