Buy 3 Get a 4th Free* | Learn More >>
4982
RIP2 Antibody

RIP2 Antibody #4982

This product is discontinued

We recommend the following alternatives

  • WB
H M R Mk
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

RIP2 Antibody detects endogenous levels of total RIP2 protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human RIP2. Antibodies are purified by protein A and peptide affinity chromatography.

Receptor Interacting Protein 2 (RIP2) is a serine/threonine kinase with a carboxy-terminal caspase activation and recruitment domain (CARD). Association of RIP2 with the tumor necrosis factor receptor (TNFR) causes activation of NF-κB and induction of apoptosis (1-3). Expression of RIP2 is induced in macrophages upon exposure to bacterial cell wall components, such as LPS. RIP2-deficient mouse models demonstrate that this kinase integrates and transduces signals for both the innate and adaptive immune system (4,5).

  1. Inohara, N. et al. (1998) J Biol Chem 273, 12296-300.
  2. McCarthy, J.V. et al. (1998) J Biol Chem 273, 16968-75.
  3. Thome, M. et al. (1998) Curr Biol 8, 885-8.
  4. Chin, A.I. et al. (2002) Nature 416, 190-4.
  5. Kobayashi, K. et al. (2002) Nature 416, 194-9.
Entrez-Gene Id
8767
Swiss-Prot Acc.
O43353
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Upstream / Downstream

pathwayImage

Explore pathways related to this product.