Upstream / Downstream
Explore pathways related to this product.
Find answers on our FAQs page.
- Additional protein information
- Analytical tools
PINK1 (N4/15.11) Mouse mAb #5660
This product is discontinued
Gallery: PINK1 (N4/15.11) Mouse mAb #5660
PINK1 (N4/15.11) Mouse mAb recognizes transfected levels of total PINK1 protein. Endogenous levels of PINK1 have not been detected with this antibody so far.
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PINK1 protein.
PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria (1-3). PINK1 phosphorylates Parkin and promotes its translocation to mitochondria (2). Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson’s disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction (1,3).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc. DRAQ5 is a registered trademark of Biostatus Limited.