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Phospho-REPS1 (Ser709) Antibody

Phospho-REPS1 (Ser709) Antibody #6884

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
H Mk

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Phospho-REPS1 (Ser709) Antibody recognizes endogenous levels of REPS1 only when phosphorylated at Ser709.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser709 of human REPS1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

REPS1 is a RalBP1-associated EH-homology domain containing protein. The sequence of REPS1 has an EH domain, followed by two proline-rich segments, and a C-terminal coiled-coil domain for binding to RalBP1 (1). The EH domain of REPS1 interacts with the NPF motif of Rab11-FIP2, mediates their colocalization to endosome vesicles, and influences EGFR endocytosis (2). The two proline-rich regions of REPS1 are important for binding to the SH3 domain of GRK/GRB2 and further regulate EGFR downstream signaling. The proline-rich regions of REPS1 have also been shown to interact with the SH3 domain of intersectin1 (ITSN1) and contribute to ITSN1/SGIP1/REPS1 complex formation on clathrin-coated pits (3). Three alternatively spliced isoforms of REPS1 have been identified.

Phosphorylation of Ser709 on REPS1 was identified at Cell Signaling Technology using PTMScan® Technology, our LC-MS/MS platform for phosphorylation site discovery (4).

  1. Yamaguchi, A. et al. (1997) J Biol Chem 272, 31230-4.
  2. Cullis, D.N. et al. (2002) J Biol Chem 277, 49158-66.
  3. Dergai, O. et al. (2010) Biochem Biophys Res Commun 402, 408-13.
  4. Rush, J. et al. (2005) Nat Biotechnol 23, 94-101.
Entrez-Gene Id
Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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Technical Support and Customer Service Closing Early Today

US Customer Service and Technical Support will be closing at 3:00 PM EST today. Any US orders placed today will ship on Tuesday, May 29.