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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

LSm2 Antibody recognizes endogenous levels of total LSm2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val77 of human LSm2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

LSm proteins are members of an ancient family of RNA binding proteins that function in RNA metabolism (1,2). Two LSm complexes or rings have been identified based on protein composition: LSm1-7 and LSm2-8 (1). The cytoplasmic LSm1-7 complex is involved in mRNA degradation (3) while the LSm2-8 ring is required for pre-tRNA and rRNA maturation (4,5) and regulation of pre-mRNA splicing through its association with U6 snRNA (6). Recent studies show that LSm2-8 complex functions in the biogenesis of telomerase RNA (1).

1.  Tang, W. et al. (2012) Nature 484, 260-4.

2.  Wilusz, C.J. and Wilusz, J. (2005) Nat Struct Mol Biol 12, 1031-6.

3.  Tharun, S. et al. (2000) Nature 404, 515-8.

4.  Kufel, J. et al. (2002) Mol Cell Biol 22, 5248-56.

5.  Kufel, J. et al. (2003) J Biol Chem 278, 2147-56.

6.  Mayes, A.E. et al. (1999) EMBO J 18, 4321-31.

Entrez-Gene Id 57819
Swiss-Prot Acc. Q9Y333

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

LSm2 Antibody