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135 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

APBA2 Antibody recognizes endogenous levels of total APBA2 protein.

Species predicted to react based on 100% sequence homology: Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe300 of human APBA2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Amyloid β A4 precursor protein-binding family A member 2 (APBA2) is a neuronal adaptor protein that interacts with the amyloid β precursor protein (APP) (1). The amyloid β-protein (Aβ) is the principal component of amyloid plaques, a pathological hallmark of Alzheimer’s disease (2). APBA2 has been shown to stabilize APP metabolism and suppress the secretion of Aβ (3). APBA2 mediates interaction between APP and the neural type I membrane protein Alcadein (Alc) by linking their cytoplasmic domains, thereby forming a tripartite complex of the three proteins in neurons (4).

1.  Sakuma, M. et al. (2009) J Neurochem 109, 465-75.

2.  Saito, Y. et al. (2008) J Biol Chem 283, 35763-71.

3.  Araki, Y. et al. (2003) J Biol Chem 278, 49448-58.

4.  Sano, Y. et al. (2006) J Biol Chem 281, 37853-60.

Entrez-Gene Id 321
Swiss-Prot Acc. Q99767

For Research Use Only. Not For Use In Diagnostic Procedures.
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APBA2 Antibody