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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

IQGAP2 Antibody recognizes endogenous levels of total IQGAP2 protein.

Species predicted to react based on 100% sequence homology: Mouse, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human IQGAP2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

IQGAPs are scaffolding proteins involved in mediating cytoskeletal function. They contain multiple protein interaction domains and bind to a growing number of molecules including actin, myosin light chain, calmodulin, E-cadherin, and β-catenin (reviewed in 1). Through their GAP-related domains, they bind the small GTPases Rac1 and cdc42. IQGAPs lack GAP activity, however, and regulate small GTPases by stabilizing their GTP-bound (active) forms (2,3). Research studies have shown that the function and distribution of the IQGAP proteins widely vary. IQGAP1 is ubiquitously expressed and has been found to interact with APC (4) and the CLIP170 complex (5) in response to small GTPases, promoting cell polarization and migration. Additional research studies have suggested that IQGAP1 could play a part in the invasiveness of some cancers (6-8). IQGAP2, which is about 60% identical to IQGAP1, is expressed primarily in liver (3), but lower levels have been detected in the prostate, kidney, thyroid, stomach, and testis (9,10). Research studies have shown that IQGAP2 displays tumor suppressor properties (11). Less is known about the function of IQGAP3, but this protein is present in the lung, brain, small intestine, and testis (9) and is only expressed in proliferating cells (12), suggesting a role in cell growth and division.

1.  Briggs, M.W. and Sacks, D.B. (2003) EMBO Rep 4, 571-4.

2.  Ho, Y.D. et al. (1999) J Biol Chem 274, 464-70.

3.  Brill, S. et al. (1996) Mol Cell Biol 16, 4869-78.

4.  Watanabe, T. et al. (2004) Dev Cell 7, 871-83.

5.  Fukata, M. et al. (2002) Cell 109, 873-85.

6.  Chew, C.S. et al. (2005) Am J Physiol Gastrointest Liver Physiol 288, G376-87.

7.  Jin, S.H. et al. (2008) Int J Cancer 122, 1040-6.

8.  Liu, Z. et al. (2010) Clin Cancer Res 16, 6009-18.

9.  Wang, S. et al. (2007) J Cell Sci 120, 567-77.

10.  Schmidt, V.A. et al. (2003) Blood 101, 3021-8.

11.  Jin, S.H. et al. (2008) Int J Cancer 122, 1040-6.

12.  Nojima, H. et al. (2008) Nat Cell Biol 10, 971-8.

Entrez-Gene Id 10788
Swiss-Prot Acc. Q13576

For Research Use Only. Not For Use In Diagnostic Procedures.
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IQGAP2 Antibody