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60 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Catalase Antibody recognizes endogenous levels of total catalase protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile165 of human catalase protein. Antibodies are purified by protein A and peptide affinity chromatography.

Catalase catalyzes the conversion of hydrogen peroxide to water and oxygen (1). Research studies show that overexpression of this antioxidant enzyme increases the ability of pancreatic β-cells to scavenge reactive oxygen species (ROS), thereby protecting pancreatic β-cells from oxidative stress (2). The pancreatic β-cells overexpressing this enzyme are also protected from hydrogen peroxide-mediated lipotoxicity, providing further evidence for the importance of catalase in the pathogenesis of diabetes (3).

1.  Chelikani, P. et al. (2004) Cell Mol Life Sci 61, 192-208.

2.  Chen, H. et al. (2005) Diabetes 54, 1437-46.

3.  Elsner, M. et al. (2011) Diabetes 60, 200-8.

Entrez-Gene Id 847
Swiss-Prot Acc. P04040

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Catalase Antibody