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8841
Catalase Antibody

Catalase Antibody #8841

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
  • IF
H XP
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Catalase Antibody recognizes endogenous levels of total catalase protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile165 of human catalase protein. Antibodies are purified by protein A and peptide affinity chromatography.

Catalase catalyzes the conversion of hydrogen peroxide to water and oxygen (1). Research studies show that overexpression of this antioxidant enzyme increases the ability of pancreatic β-cells to scavenge reactive oxygen species (ROS), thereby protecting pancreatic β-cells from oxidative stress (2). The pancreatic β-cells overexpressing this enzyme are also protected from hydrogen peroxide-mediated lipotoxicity, providing further evidence for the importance of catalase in the pathogenesis of diabetes (3).

  1. Chelikani, P. et al. (2004) Cell Mol Life Sci 61, 192-208.
  2. Chen, H. et al. (2005) Diabetes 54, 1437-46.
  3. Elsner, M. et al. (2011) Diabetes 60, 200-8.
Entrez-Gene Id
847
Swiss-Prot Acc.
P04040
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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