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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

AGR2 Antibody recognizes endogenous levels of total AGR2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala29 of human AGR2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Anterior gradient homolog 2 (AGR2) is a member of the protein disulfide isomerase (PDI) family of proteins and a homolog of the Xenopus laevis cement gland protein (1). In normal human tissues, AGR2 is expressed most abundantly in intestinal cells. Research studies have found AGR2 is overexpressed in a number of adenocarcinomas, including those derived from breast, pancreas, ovary, prostate and esophagus (2-4). In vitro and in vivo studies have shown that AGR2 positively regulates cell growth and division, while its overexpression can promote cell transformation (5,6). The latter functions of AGR2 were shown to involve YAP1-mediated up-regulation of amphiregulin expression, implicating AGR2 in both the EGF and Hippo kinase signaling pathways (6).

1.  Maresh, E.L. et al. (2010) BMC Cancer 10, 680.

2.  Pizzi, M. et al. (2012) Appl Immunohistochem Mol Morphol 20, 31-6.

3.  Wang, Z. et al. (2008) Cancer Res 68, 492-7.

4.  Park, K. et al. (2011) Exp Mol Med 43, 91-100.

5.  Vanderlaag, K.E. et al. (2010) Breast Cancer Res 12, R32.

6.  Dong, A. et al. (2011) J Biol Chem 286, 18301-10.

Entrez-Gene Id 10551
Swiss-Prot Acc. O95994

For Research Use Only. Not For Use In Diagnostic Procedures.
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AGR2 Antibody