Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Fragilis Antibody recognizes endogenous levels of total fragilis protein.
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln16 of mouse fragilis protein. Antibodies are purified by protein A and peptide affinity chromatography.
Fragilis (Ifitm3) belongs to the interferon (IFN)-inducible transmembrane protein family (1), which consists of five highly similar transmembrane proteins that are conserved among mammalian species (2). It is thought to be the first gene to mark the onset of germ cell competence during embryonic development in mice (3). Cells expressing high levels of fragilis protein go on to express stella, a protein found exclusively in lineage-restricted germ cells (3). Studies on fragilis family members could help elucidate the mechanisms through which interferons act as signaling molecules during embryonic development (2).
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