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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Dectin-1 Antibody recognizes endogenous levels of total Dectin-1 protein. This antibody cross-reacts with an 80 kDa protein of unknown origin. Alternative splicing of the Dectin-1 transcript can lead to eight isoforms with predicted molecular weights ranging from 5-27 kDa. Glycosylation causes Dectin-1 to run higher than its predicted molecular weight.

Species predicted to react based on 100% sequence homology: Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Dectin-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Dectin-1 is a C-type lectin receptor expressed by macrophages, monocytes, dendrtic cells, neutrophils, and a subset of γδ T cells (1,2). Dectin-1 is a glycoprotein with eight different isoforms, generated through alternative splicing (3-5). It plays an important role in anti-fungal immunity by acting as a pattern recognition receptor for β-glucans found on the cell wall of fungi and some bacteria (5,6). Dectin-1 is composed of a short amino-terminal cytoplasmic domain containing an ITAM-like motif, a transmembrane domain, and an extracellular carboxy-terminal C-type lectin domain (5). Dectin-1 recognizes β-glucans through its C-type lectin domain and transduces signals through its ITAM-like motif by recruiting and activating Syk (7,8). Dendritic cells activated through Dectin-1 promote differentiation of Th17 cells by producing IL-6 and IL-23 (9).

1.  Taylor, P.R. et al. (2002) J Immunol 169, 3876-82.

2.  Martin, B. et al. (2009) Immunity 31, 321-30.

3.  Ariizumi, K. et al. (2000) J Biol Chem 275, 20157-67.

4.  Kato, Y. et al. (2006) Biol Pharm Bull 29, 1580-6.

5.  Willment, J.A. et al. (2001) J Biol Chem 276, 43818-23.

6.  Brown, G.D. and Gordon, S. (2001) Nature 413, 36-7.

7.  Rogers, N.C. et al. (2005) Immunity 22, 507-17.

8.  Underhill, D.M. et al. (2005) Blood 106, 2543-50.

9.  LeibundGut-Landmann, S. et al. (2007) Nat Immunol 8, 630-8.

Entrez-Gene Id 64581
Swiss-Prot Acc. Q9BXN2

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Dectin-1 Antibody