Upstream / Downstream


Explore pathways related to this product.

Our U.S. Offices Are Closed

Our U.S. offices are closed in observance of Memorial Day. We will reopen on Tuesday, May 30th.

Thank you for your patience.


Find answers on our FAQs page.


PhosphoSitePlus® Resource

  • Additional protein information
  • Analytical tools


We recommend the following alternatives

W IP     F   H
14-45 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Dectin-1 Antibody recognizes endogenous levels of total Dectin-1 protein. This antibody cross-reacts with an 80 kDa protein of unknown origin. Alternative splicing of the Dectin-1 transcript can lead to eight isoforms with predicted molecular weights ranging from 5-27 kDa. Glycosylation causes Dectin-1 to run higher than its predicted molecular weight.

Species predicted to react based on 100% sequence homology: Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Dectin-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Dectin-1 is a C-type lectin receptor expressed by macrophages, monocytes, dendrtic cells, neutrophils, and a subset of γδ T cells (1,2). Dectin-1 is a glycoprotein with eight different isoforms, generated through alternative splicing (3-5). It plays an important role in anti-fungal immunity by acting as a pattern recognition receptor for β-glucans found on the cell wall of fungi and some bacteria (5,6). Dectin-1 is composed of a short amino-terminal cytoplasmic domain containing an ITAM-like motif, a transmembrane domain, and an extracellular carboxy-terminal C-type lectin domain (5). Dectin-1 recognizes β-glucans through its C-type lectin domain and transduces signals through its ITAM-like motif by recruiting and activating Syk (7,8). Dendritic cells activated through Dectin-1 promote differentiation of Th17 cells by producing IL-6 and IL-23 (9).

1.  Taylor, P.R. et al. (2002) J Immunol 169, 3876-82.

2.  Martin, B. et al. (2009) Immunity 31, 321-30.

3.  Ariizumi, K. et al. (2000) J Biol Chem 275, 20157-67.

4.  Kato, Y. et al. (2006) Biol Pharm Bull 29, 1580-6.

5.  Willment, J.A. et al. (2001) J Biol Chem 276, 43818-23.

6.  Brown, G.D. and Gordon, S. (2001) Nature 413, 36-7.

7.  Rogers, N.C. et al. (2005) Immunity 22, 507-17.

8.  Underhill, D.M. et al. (2005) Blood 106, 2543-50.

9.  LeibundGut-Landmann, S. et al. (2007) Nat Immunol 8, 630-8.

Entrez-Gene Id 64581
Swiss-Prot Acc. Q9BXN2

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Dectin-1 Antibody