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Lefty1 Antibody

Lefty1 Antibody #9620

This product is discontinued

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Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Lefty1 Antibody recognizes transfected levels of total lefty1 protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro233 of human lefty1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Lefty proteins are members of the TGF-β family of cell signaling molecules that are involved in growth and development (1,2). Named for their role in left-right axis determination and their exclusive expression on the left side of the developing mouse embryo, lefty1 and lefty2 contain a cysteine-knot motif that is characteristic of TGF-β related proteins, but lack an alpha-helix and a cysteine residue critical for ligand dimerization (3). Early in vertebrate embryogenesis, lefty represses TGF-β signaling by inhibiting the phosphorylation of Smad2 following activation of the TGF-β receptor (4). Down-regulated very early upon differentiation (5), lefty proteins act as extracellular antagonists of the signaling pathway for Nodal, a TGF-β ligand critical for left-right patterning and formation of the mesoderm and endoderm (6). Similar to other members of the TGF-β superfamily, lefty proproteins undergo cleavage to release a bioactive protein (7). The biologically active 42 kDa lefty precursor and the 28 kDa polypeptide have been shown to induce MAPK activity (7).

  1. Kingsley, D.M. (1994) Genes Dev 8, 133-46.
  2. Heldin, C.H. et al. (1997) Nature 390, 465-71.
  3. Meno, C. et al. (1997) Genes Cells 2, 513-24.
  4. Ulloa, L. and Tabibzadeh, S. (2001) J Biol Chem 276, 21397-404.
  5. Besser, D. (2004) J Biol Chem 279, 45076-84.
  6. Schier, A.F. (2003) Annu Rev Cell Dev Biol 19, 589-621.
  7. Ulloa, L. et al. (2001) J Biol Chem 276, 21387-96.
Entrez-Gene Id
Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

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