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9983
NCBP1/CBP80 Antibody

NCBP1/CBP80 Antibody #9983

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
H M R Mk
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

NCBP1/CBP80 recognizes endogenous levels of total NCBP1/CBP80 protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val452 of human NCBP1/CBP80 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Nuclear cap-binding protein subunit 1 (NCBP1), also known as cap-binding protein 80 (CBP80), plays a role in nuclear pre-mRNA splicing (1,2). It has also been shown to function in the nonsense-mediated decay (NMD) of mRNAs where translation is prematurely terminated (3). NCBP1/CBP80 increases the efficiency of NMD by promoting the interaction of two active NMD components Upf1 and Upf2 (4).

  1. Izaurralde, E. et al. (1994) Cell 78, 657-68.
  2. Izaurralde, E. et al. (1995) Nature 376, 709-12.
  3. Ishigaki, Y. et al. (2001) Cell 106, 607-17.
  4. Hosoda, N. et al. (2005) Nat Struct Mol Biol 12, 893-901.
Entrez-Gene Id
4686
Swiss-Prot Acc.
Q09161
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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