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80 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

NCBP1/CBP80 recognizes endogenous levels of total NCBP1/CBP80 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val452 of human NCBP1/CBP80 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Nuclear cap-binding protein subunit 1 (NCBP1), also known as cap-binding protein 80 (CBP80), plays a role in nuclear pre-mRNA splicing (1,2). It has also been shown to function in the nonsense-mediated decay (NMD) of mRNAs where translation is prematurely terminated (3). NCBP1/CBP80 increases the efficiency of NMD by promoting the interaction of two active NMD components Upf1 and Upf2 (4).

1.  Izaurralde, E. et al. (1994) Cell 78, 657-68.

2.  Izaurralde, E. et al. (1995) Nature 376, 709-12.

3.  Ishigaki, Y. et al. (2001) Cell 106, 607-17.

4.  Hosoda, N. et al. (2005) Nat Struct Mol Biol 12, 893-901.

Entrez-Gene Id 4686
Swiss-Prot Acc. Q09161

For Research Use Only. Not For Use In Diagnostic Procedures.
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NCBP1/CBP80 Antibody