Product Pathways - Metabolism
CYP3A4 (D9U6N) Rabbit mAb #13384
|13384S||100 µl (10 western blots)||---||In Stock||---|
|13384||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse||Endogenous||50||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
CYP3A4 (D9U6N) Rabbit mAb recognizes endogenous levels of total CYP3A4 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CYP3A4 protein.
Cytochrome P450, subfamily 3A, polypeptide 4 (CYP3A4) is a mono-oxygenase enzyme (1) found in the endoplasmic reticulum membrane of liver and prostate microsomes. It is an important enzyme in drug metabolism; it catalyzes phase I oxidation reactions in approximately 50% of drugs in the modern market, as well as steroids, fatty acids, and some carcinogens (2). It is also involved in steroid and cholesterol synthesis (3,4). Expression of CYP3A4 can be induced by glucocorticoids, carcinogens, pesticides, and drugs, which can lead to drug interactions and toxicity (5).
- Gupta, R.P. et al. (2004) J Bone Miner Res 19, 680-8.
- Lynch, T. and Price, A. (2007) Am Fam Physician 76, 391-6.
- Pikuleva, I.A. (2006) Pharmacol Ther 112, 761-73.
- Tompkins, L.M. and Wallace, A.D. (2007) J Biochem Mol Toxicol 21, 176-81.
- Thummel, K.E. and Wilkinson, G.R. (1998) Annu Rev Pharmacol Toxicol 38, 389-430.
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