Revision 1

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Store at -20C

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Orders:

877-616-CELL (2355)

[email protected]

Support:

877-678-TECH (8324)

3 Trask Lane | Danvers | Massachusetts | 01923 | USA

For Research Use Only. Not for Use in Diagnostic Procedures.

Background

Bavdegalutamide (ARV-110) is an androgen receptor (AR) proteolysis targeting chimeric (PROTAC) degrader being studied for prostate cancer treatment (1). AR signaling plays a pivotal role in the development of prostate cancer, and while current therapies already target AR signaling, AR alterations can occur as prostate cancer progresses. These alterations can become resistant to traditional therapies, which are predominantly used to block the AR (1,2). Bavdegalutamide (ARV-110) operates differently by promoting AR protein ubiquitination and degradation and has been known to inhibit cellular growth in VCaP (IC50 = 1.5 nM) and LNCaP (IC50 = 16.2 nM) cell lines (2). Bavdegalutamide (ARV-110) binds to the AR and then recruits an E3 ubiquitin ligase to tag the AR for degradation (1). Bavdegalutamide (ARV-110) is also currently being used in clinical trials to investigate its effects in patients with metastatic castration-resistant prostate cancer (1).

Molecular Formula

C41H43CIFN9O6

Molecular Weight

812.3 g/mol

Purity

98%

CAS

2222112-77-6

Solubility

Soluble in DMSO at 25 mg/mL.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Directions for Use

Bavdegalutamide (ARV-110) is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 5 mg of powder in 1.23 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Trademarks and Patents

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

Orders: 877-616-CELL (2355) [email protected] Support: 877-678-TECH (8324) [email protected] Web: cellsignal.com
For Research Use Only. Not for Use in Diagnostic Procedures.

Revision 1

Cell Signaling Technology Logo
Chemical structure of Bavdegalutamide (ARV-110).
undefined Image 1: Bavdegalutamide (ARV-110)
Orders: 877-616-CELL (2355) [email protected] Support: 877-678-TECH (8324) [email protected] Web: cellsignal.com
For Research Use Only. Not for Use in Diagnostic Procedures.