Product Pathways - Lymphocyte Signaling
CD2AP Antibody #2135
|2135S||100 µl (10 western blots)||---||In Stock||---|
|2135||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||80||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
CD2AP Antibody detects endogenous levels of total CD2AP protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids near the carboxy terminus of human CD2AP. Antibodies are purified by protein A and peptide affinity chromatography.
CD2AP is a scaffolding protein that is thought to link membrane proteins to the cytoskeleton (1-3). It plays a role in formation of tight junctions in specialized cell types such as the slit diaphragm in the kidney glomerulus (4). CD2AP is also involved in the immunological synapse between CD2 expressing T cells and antigen presenting cells (5). It has been shown that interaction between CD2AP and other cytoskeletal proteins may regulate the endocytosis of EGFR (3).
- Kirsch, K.H. et al. (1999) Proc. Natl. Acad. Sci. USA 96, 6211-6216.
- Kirsch, K.H. et al. (2001) J. Biol. Chem. 276, 4957-4963.
- Lynch, D.K. et al. (2003) J. Biol. Chem. 278, 21805-21813.
- Kawachi, H. et al. (2006) Nephrology (Carlton) 11, 274-281.
- Hutchings, N.J. et al. (2003) J. Biol. Chem. 278, 22396-22403.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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