Product Pathways - Lymphocyte Signaling
CD8 (RIV11) Mouse mAb #3572
|3572S||400 µl (100 tests)||---||In Stock||---|
|3572||carrier free and custom formulation / quantity||email request|
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Applications Key: F=Flow Cytometry
Specificity / Sensitivity
CD8 (RIV11) Mouse mAb detects endogenous levels of total CD8 protein.
Source / Purification
Monoclonal antibody is produced by immunizing BALB/c mice with human peripheral lymphocytes.
Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8 α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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