Product Pathways - Cytoskeletal Signaling
Dynamin-I (3G4B6) Mouse mAb #4565
|4565S||100 µl (10 western blots)||---||In Stock||---|
|4565||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||100||Mouse IgG2a|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
Dynamin-I (3G4B6) Mouse mAb detects endogenous levels of total dynamin-I protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a recombinant carboxy-terminal fragment of human dynamin-I.
Dynamin is a family of large GTPases that has been implicated in the formation of vesicles of both the endocytotic and secretory processes (1). Dynamin plays an important role in the internalization of cell surface receptors, a process that attenuates the response to extracellular signals. It has been illustrated that dynamin interacts with signaling proteins such as Src, PLCγ, PKC and G-proteins. PKC and Src phosphorylate dynamin, and its phosphorylation may regulate the endocytosis of cell surface receptors (2,3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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