Product Pathways - PI3K / Akt Signaling
RagB (D18F3) Rabbit mAb #8150
|8150S||100 µl (10 western blots)||---||In Stock||---|
|8150||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Monkey||Endogenous||40||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
RagB (D18F3) Rabbit mAb recognizes endogenous levels of total RagB protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human RagB protein.
The mTORC1 kinase complex is a critical regulator of cell growth (1,2). Its activity is modulated by energy levels, growth factors, and amino acids via signaling through Akt, MAPK, and AMPK pathways (3,4). Recent studies found that the four related GTPases, RagA, RagB, RagC, and RagD, interact with raptor within the mTORC1 complex (1,2). These interactions are both necessary and sufficient for mTORC1 activation in response to amino acid signals (1,2).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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