Product Pathways - Lymphocyte Signaling
MNDA (3C1) Rat mAb (Alexa Fluor® 488 Conjugate) #9283
|9283S||100 µl (50 tests)||---||In Stock||---|
|9283||carrier free and custom formulation / quantity||email request|
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Applications Key: IF-IC=Immunofluorescence (Immunocytochemistry), F=Flow Cytometry
Specificity / Sensitivity
MNDA (3C1) Rat mAb (Alexa Fluor® 488 Conjugate) detects endogenous levels of total MNDA protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a nuclear extract from human granulocytes.
Flow cytometric analysis of Jurkat cells (blue) and THP-1 cells (green) using MNDA (3C1) Rat mAb (Alexa Fluor® 488 Conjugate).
This Cell Signaling Technology antibody is conjugated to Alexa Fluor® 488 fluorescent dye and tested in-house for direct flow cytometric analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated MNDA (3C1) Rat mAb #3329.
MNDA (myeloid cell nuclear differentiation antigen) is a transcription factor constitutively expressed in peripheral blood granulocytes and monocytes; low expression is also found in a subset of B cells (1,2). MNDA is a member of the interferon (IFN)-regulated 200 family of genes, which contain one or more copies of a partially conserved domain of 200 amino acid residues thought to mediate protein-protein interaction (3). MNDA may play a role in apoptosis and its expression is reduced in myelodysplastic syndromes (MDS) (4). MNDA has been proposed to be a marker for nodal marginal zone lymphoma (5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
The Alexa Fluor® dye antibody conjugates in this product are sold under license from Molecular Probes, Inc., for research use only, except for use in combination with DNA microarrays. The Alexa Fluor® dyes (except for Alexa Fluor® 430 dye) are covered by pending and issued patents. Alexa Fluor® is a registered trademark of Molecular Probes, Inc.