Render Target: STATIC
Render Timestamp:
6/8/2026, 6:46:53 AM EDT
6/8/2026, 10:46:53 AM UTC
Commit: 33ae406c5df2bbc7a7d3c17605228fbeff8ea416
XML generation date: 2026-06-02 18:18:17.602
Product last modified at: 2026-06-02T07:00:59.620Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
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SEC62 (F4T2S) Rabbit Monoclonal Antibody #99577

Filter:
  • WB
  • IP
  • IF

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 55
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50
    Immunoprecipitation 1:200
    Immunofluorescence (Frozen) 1:200 - 1:800
    Immunofluorescence (Immunocytochemistry) 1:400 - 1:1600

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SEC62 (F4T2S) Rabbit Monoclonal Antibody recognizes endogenous levels of total SEC62 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro280 of human SEC62 protein.

    Background

    SEC62 is an endoplasmic reticulum (ER) transmembrane protein and a core component of the mammalian SEC61 translocon, the complex responsible for the post-translational translocation of proteins into the ER lumen or their integration into the ER membrane. Along with SEC63 and the luminal chaperone BiP, SEC62 recognizes specific signal sequences that bypass the traditional signal recognition particle (SRP) pathway. This complex is essential for the post-translational translocation of small pre-secretory proteins (1). SEC62 also interacts with SEC61 to regulate the passive leakage of calcium from the ER into the cytosol and maintain calcium homeostasis (2). Additionally, SEC62 acts as an autophagy receptor during recovery from ER stress, binding to LC3 to initiate the delivery of excess ER components to autophagosomes for degradation (3). SEC62 is frequently overexpressed in various human cancers, most notably in prostate, thyroid, and non-small cell lung cancers, and is often used as a prognostic marker (4). High levels of SEC62 can provide a protective advantage to tumor cells by enhancing their ability to survive ER stress via ER-phagy and calcium regulation (5,6). Therefore, combining ER-stress inducing therapies, such as thapsigargin, with strategies to inhibit SEC62, such as the calmodulin antagonist trifluoperazine, is a promising strategy for treating SEC62-overexpressing tumors (7,8).

    Alternate Names

    Dtrp1; FLJ32803; hTP-1; HTP1; membrane protein SEC62, S.cerevisiae, homolog of; SEC62; SEC62 homolog (S. cerevisiae); SEC62 homolog, preprotein translocation factor; SEC62 preprotein translocation factor; TLOC1; TP-1; Translocation protein 1; Translocation protein SEC62

    For Research Use Only. Not for Use in Diagnostic Procedures.
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