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82556
BC-11-38
Activators & Inhibitors
Chemical Modulators

BC-11-38 #82556

Citations (0)
Chemical structure of BC-11-38.

Product Usage Information

BC-11-38 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.10 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 304.4 g/mol
Purity >98%
Molecular Formula C15H16N2OS2
CAS 68770-80-9
Solubility Soluble in DMSO at 50 mg/mL or ethanol at 14 mg/mL.

Background

The small-molecule BC-11-38 is an inhibitor of dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (PDE11), which catalyzes hydrolysis of the second messengers cyclic guanosine 3', 5'-monophosphate (cGMP) and cyclic AMP (cAMP) in intracellular signaling regulation. BC-11-38 is a selective and potent inhibitor of PDE11, displaying IC50 values of less than 330 nM for PDE11 and a greater than 100-fold selectivity for PDE11 relative to other PDE isozymes. BC-11-38 treatment of human adrenocortical cells inhibited PDE11 and resulted in increased cAMP levels, cAMP-dependent protein kinase (PKA) activity, and cortisol production (1,2). At the time of its identification, BC-11-38 was thought of as a potential therapeutic target for the treatment of renal insufficiency (3).

Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not for Use in Diagnostic Procedures.
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To Purchase # 82556
Cat. # Size Qty. Price
82556S
10 mg