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81178
Beta-d-N4-Hydroxycytidine
Activators & Inhibitors
Chemical Modulators

Beta-d-N4-Hydroxycytidine #81178

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Beta-d-N4-Hydroxycytidine: Image 1
Chemical structure of Beta-d-N4-Hydroxycytidine.

Product Usage Information

Beta-d-N4-Hydroxycytidine is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.28 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 259.2 g/mol
Purity >98%
Molecular Formula C9H13N3O6
CAS 3258-02-4
Solubility Soluble in DMSO at 25 mg/ml or water at 15 mg/ml with slight warming.

Background

Beta-d-N4-Hydroxycytidine, also known as EIDD-1931, is a nucleic acid base analog and a specific AT to GC mutagen formed by the treatment of nucleoside cytidine with hydroxylamine (1). Beta-d-N4-Hydroxycytidine acts as a competitive substrate for viral encoded RNA polymerase and has demonstrated broad in vitro antiviral activity, including Chikungunya virus, Ebola, and Hepatitis C (2-4). Beta-d-N4-Hydroxycytidine demonstrated an IC50 value of 0.1 µM and an IC90 value of 6 µM in SARS-CoV infected Vero cells (5,6).
  1. Janion, C. and Glickman, B.W. (1980) Mutat Res 72, 43-7.
  2. Ehteshami, M. et al. (2017) Antimicrob Agents Chemother 61, e02395-16. doi: 10.1128/AAC.02395-16.
  3. Reynard, O. et al. (2015) Viruses 7, 6233-40.
  4. Stuyver, L.J. et al. (2003) Antimicrob Agents Chemother 47, 244-54.
  5. Barnard, D.L. et al. (2006) Antivir Chem Chemother 17, 275-84.
  6. Barnard, D.L. et al. (2004) Antivir Chem Chemother 15, 15-22.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 81178
Cat. # Size Qty. Price
81178S
5 mg $ 98