Product Information
Molecular Weight | 322.3 g/mol |
Purity | >98% |
Molecular Formula | C18H14N2O4 |
CAS | 304448-55-3 |
Solubility | Soluble in DMSO at 30 mg/mL or ethanol at 1 mg/mL. |
Dynasore is a cell-permeable, small-molecule inhibitor of the endocytosis-associated GTPase dynamin (IC50 = 15 mM). Dynamin promotes clathrin-coated vesicle formation and is involved in detaching coated pits from the membrane during clathrin-mediated endocytosis. Dynasore inhibits the GTPase activity of dynamin I, dynamin II, dynamin-related protein 1, and mitochondrial dynamin. By blocking dynamin, Dynasore inhibits coated vesicle formation and dynamin-mediated endocytic pathways (1). In a study of hippocampal synapses, inhibition by Dynasore demonstrated that dynamin is essential for all forms of synaptic vesicle endocytosis, and that Dynasore has no effect on exocytosis (2). A study of hepatocellular carcinoma demonstrated that Dynasore enhanced the inhibitory effects of c-Met inhibitors on hepatoma cell proliferation and migration, and led to increased cell cycle arrest and apoptosis (3). Dynasore blocked HSV-1 entry into human and murine keratinocytes, and prevented HSV-1 and HSV-2 infection of human epithelial and neuronal cells, including primary genital tract cells and human fetal neurons and astrocytes (4).
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Cat. # | Size | Qty. | Price |
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46240S | 5 mg |
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