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INK128 #30690

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INK128: Image 1
Western blot analysis of extracts from 293T cells, untreated (-) or treated with INK128 (100 nM, 1 hr; +), using Phospho-p70 S6 Kinase (Thr389) (D5U1O) Rabbit mAb #97596 (upper), or p70 S6 Kinase (49D7) Rabbit mAb #2708 (lower).
INK128: Image 2
Chemical structure of INK128.

Product Usage Information

INK128 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.07 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 309.3 g/mol
Purity >98%
Molecular Formula C15H15N7O
CAS 1224844-38-5
Solubility Soluble in DMSO at 25 mg/ml.


INK128, also known as MLN0128, is a second-generation active-site mTOR inhibitor (asTORi). Treating cells with INK128 leads to the dephosphorylation of mTOR downstream targets including p70 S6 kinase and 4E-BP1 (1,2). Research has proven that INK128 is an effective mTOR inhibitor because it targets both the mTORC1 and mTORC2 complexes at a high potency (Ki = 1.4nM) (1). Studies have shown that INK128 has anti-leukemic effects and can induce apoptosis at higher concentrations (3).
  1. Hsieh, A.C. et al. (2012) Nature 485, 55-61.
  2. Vilar, E. et al. (2011) Mol Cancer Ther 10, 395-403.
  3. Zeng, Z. et al. (2016) Oncotarget 7, 55083-55097.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
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To Purchase # 30690
Cat. # Size Qty. Price
5 mg
$ 84