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84566
(+)-JQ1
Activators & Inhibitors
Chemical Modulators

(+)-JQ1 #84566

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(+)-JQ1: Image 1

Chemical structure of (+)-JQ1.

Product Usage Information

(+)-JQ1 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.09 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 457 g/mol
Purity

>98%

Molecular Formula

C23H25ClN4O2S

CAS 1268524-70-4
Solubility Soluble in DMSO at 60 mg/ml or ethanol at 46 mg/ml.

Background

(+)-JQ1 is a potent BET bromodomain inhibitor with IC50 values of 77 nM and 33 nM for BRD4 bromodomain 1 and BRD4 bromodomain 2, respectively. This small molecule competitively binds to the acetyl-lysine recognition pocket of BET bromodomains, which in turn displaces BET proteins from chromatin (1). The BET family of proteins are associated in many different cellular processes, including mitosis, viral/host interaction, and inflammatory gene expression (2-4). Studies have shown that (+)-JQ1 induced autophagy through LKB1/AMPK pathway activation can inhibit bladder cancer (BC) cell proliferation (5).

  1. Filippakopoulos, P. et al. (2010) Nature 468, 1067-73.
  2. Huang, B. et al. (2009) Mol Cell Biol 29, 1375-87.
  3. Abbate, E.A. et al. (2006) Mol Cell 24, 877-89.
  4. Yang, Z. et al. (2008) Mol Cell Biol 28, 967-76.
  5. Li, F. et al. (2019) Cancer Med 8, 4792-805.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 84566S
Product # Size Price
84566S
5 mg $ 129