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MDL-28170 (Calpain Inhibitor III)
Activators & Inhibitors
Chemical Modulators

MDL-28170 (Calpain Inhibitor III) #10727

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MDL-28170 (Calpain Inhibitor III): Image 1
Chemical structure of MDL-28170 (Calpain Inhibitor III).

Product Usage Information

MDL-28170 (Calpain Inhibitor III) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.30 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 382.5 g/mol
Purity >98%
Molecular Formula C22H26N2O4
CAS 88191-84-8
Solubility Soluble in DMSO at 75 mg/ml.


MDL-28170 (Calpain Inhibitor III) is a potent and selective inhibitor of Calpain-1 (mu-type) and Calpain-2 (M-type) (1). This cell-permeable small molecule has been shown to cross the blood-brain barrier and has demonstrated neuroprotective effects in several rodent models making it a useful tool for studying neurodegenerative disease and neurotrauma as well as ischemic reperfusion (2,3). MDL-28170 (Calpain Inhibitor III) has an EC50 value of 14 μM when tested in a cell-based assay and has shown to be an effective antiviral agent, inhibiting SARS-CoV replication in Vero 76 cells with an IC50 value of 10 μM (4,5).
  1. Mehdi, S. (1991) Trends Biochem Sci 16, 150-3.
  2. Thompson, S.N. et al. (2010) J Neurotrauma 27, 2233-43.
  3. Urthaler, F. et al. (1997) Cardiovasc Res 35, 60-7.
  4. Seyb, K.I. et al. (2008) J Biomol Screen 13, 870-8.
  5. Barnard, D.L. et al. (2004) Antivir Chem Chemother 15, 15-22.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
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To Purchase # 10727
Cat. # Size Qty. Price
5 mg
$ 50