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61401
Poly(I:C) Sodium Salt
Activators & Inhibitors
Chemical Modulators

Poly(I:C) Sodium Salt #61401

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Poly(I:C) Sodium Salt: Image 1

Western blot analysis of extracts from THP-1 cells differentiated with TPA (12-O-Tetradecanoylphorbol-13-Acetate) #4174 (80 nM, 18 hr) and then untransfected (-) or transfected with Poly(I:C) Sodium Salt (5 μg/ml, 6 hr; +), using Phospho-IRF-3 (Ser396) (4D4G) Rabbit mAb #4947 (upper), IRF-3 (D6I4C) XP® Rabbit mAb #11904 (middle), or β-Tubulin (D2N5G) Rabbit mAb #15115 (lower).

Product Usage Information

Poly(I:C) Sodium Salt is supplied as a lyophilized powder. To prevent denaturation, reconstitute in water containing physiological salt concentrations. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Purity

>98%

CAS 42424-50-0
Solubility Soluble in water at 10 mg/ml with warming.

Background

Poly(I:C) Sodium Salt, also known as polyinosinic-polycytidylic acid sodium salt, is a synthetic analog to double-stranded RNA (dsRNA) and potent activator of Toll-like receptor 3 (TLR3). The Toll-like receptor (TLR) family plays an important role in the innate immune response (1). TLR3 functions as a receptor for dsRNA typically associated with viral infection (2). Binding of dsRNA, or the analog Poly(I:C), to TLR3 triggers activation of transcription factors NF-κB and IRF3 through the adaptor protein TICAM-1/TRIF (3,4). Studies have shown that combination treatment with Poly(I:C) can increase vaccine immunogenicity against viral and cancerous diseases (5,6).

  1. Alexopoulou, L. et al. (2001) Nature 413, 732-8.
  2. Medzhitov, R. et al. (1997) Nature 388, 394-7.
  3. Horng, T. et al. (2001) Nat Immunol 2, 835-41.
  4. Oshiumi, H. et al. (2003) Nat Immunol 4, 161-7.
  5. Liu, C. et al. (2018) Hum Vaccin Immunother 14, 931-40.
  6. Zhou, C.X. et al. (2014) BMC Vet Res 10, 2.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.
To Purchase # 61401S
Product # Size Price
61401S
25 mg $ 215