Product Information
| Molecular Weight | 364.8 g/mol |
| Purity | >98% |
| Molecular Formula | C17H17ClN2O5 |
| CAS | 305834-79-1 |
| Solubility | Soluble in DMSO at 100 mg/mL or ethanol at 40 mg/mL. |
The small-molecule SC-79 activates cytosolic Akt (PKB, protein kinase B) and inhibits Akt translocation to the membrane. Binding of SC-79 to Akt promotes interaction between Akt and the protein kinase PDK1, leading to phosphorylation of Akt at Thr308 and Ser473 (1). In a mouse model of acute liver failure, SC-79 treatment protects hepatocytes from apoptosis by inhibiting Akt-mediated aggregation of Fas and by blocking recruitment of FADD and procaspase-8 into the death-inducing signaling complex (2). Likewise, SC-79 protects hepatocytes from tumor necrosis factor-α (TNF-α)-induced apoptosis and mice from induced liver injury and damage (3). In a rat model of alcohol-induced osteonecrosis, SC-79 exposure leads to activation of cytosolic Akt and attenuation of bone tissue morphological changes (4). SC-79 treatment of neuroblastoma cells and murine dopaminergic neurons leads to Akt activation and protection from hydrogen peroxide-induced apoptosis and necrosis (5).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 90851S | 5 mg |
|
