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Chemical Modulators

Tigecycline #88058

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Tigecycline: Image 1
Chemical structure of Tigecycline.

Product Usage Information

Tigecycline is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.13 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 585.7 g/mol
Purity >98%
Molecular Formula C29H39N5O8
CAS 220620-09-7
Solubility Soluble in DMSO at 25 mg/ml.


Tigecycline, also known as GAR-936, is a broad spectrum glycylcycline antimicrobial that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA. This prevents protein synthesis and limits bacterial growth. Tigecycline has a 9-t-butyl-glycylamido side chain on the central skeleton, giving it the ability to overcome most tetracycline resistance mechanisms (1). In vitro studies have shown that Tigecycline has activity against multidrug-resistant Gram-negative and -positive bacteria, vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE), and penicillin-resistant Streptococcus (1,2). Studies have also found that Tigecycline can selectively kill human leukemia stem and progenitor cells with no disruption to normal hematopoietic cells (3). This small compound has been shown to induce apoptosis and inhibit cell proliferation in cervical cancers by suppressing the Wnt/β-catenin signaling pathway (4).
  1. Pankey, G.A. (2005) J Antimicrob Chemother 56, 470-80.
  2. Greer, N.D. (2006) Proc (Bayl Univ Med Cent) 19, 155-61.
  3. Skrtić, M. et al. (2011) Cancer Cell 20, 674-88.
  4. Li, H. et al. (2015) Biochem Biophys Res Commun 467, 14-20.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 88058
Cat. # Size Qty. Price
10 mg
$ 112