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Activators & Inhibitors
Chemical Modulators

Valinomycin #49615

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Valinomycin: Image 1
Chemical structure of Valinomycin.

Product Usage Information

Valinomycin is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 10 mg of powder in 900 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 1111.3 g/mol
Purity >98%
Molecular Formula C54H90N6O18
CAS 2001-95-8
Solubility Soluble in DMSO at 25 mg/ml or ethanol at 25 mg/ml.


Valinomycin, also known as NSC 122023, is a naturally occurring antibiotic consisting of a cyclized dodecadepsipeptide isolated from various strains of the genus Streptomyces. Valinomycin is a highly selective potassium ionophore that transports K+ across lipid membranes inducing cell death through depolarization of the mitochondrial membrane (1). Studies have investigated the critical role of potassium in viral infections (2). Valinomycin has demonstrated the ability to block viral fusion with endosomal membranes, affecting viral transcription and inhibiting viral replication, by collapsing the membrane potential (3,4). Research studies of severe acute respiratory syndrome (SARS) viral replication in Vero E6 cells identified Valinomycin as the most potent inhibitor (EC50 = 0.85 μM) as compared with other possible treatments, such as Reserpine (EC50 = 3.4 μM) and Aescim (EC50 = 6.0 μM) (5).
  1. Abdalah, R. et al. (2006) Neurosci Lett 405, 68-73.
  2. Punch, E.K. et al. (2018) J Biol Chem 293, 9937-44.
  3. Norris, M.J. et al. (2018) Am J Respir Cell Mol Biol 59, 733-44.
  4. Berka, U. et al. (2009) J Virol 83, 3778-87.
  5. Wu, C.Y. et al. (2004) Proc Natl Acad Sci U S A 101, 10012-7.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 49615
Cat. # Size Qty. Price
10 mg $ 62