Vandetanib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 5 mg in 1.05 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 1-10 µM for 0.5-2 hr prior to treating with a stimulator. It can also be used alone, with varying treatment times lasting up to 24 hr. Soluble in DMSO at 30 mg/ml; soluble in ethanol at 10 mg/ml with warming; very poorly soluble in water with maximum ~10-20 µM.
Store lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
|Molecular Weight||475.35 g/mol|
|Solubility||Soluble in DMSO at 30mg/ml and EtOH at 10mg/ml.|
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