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49079
Verapamil (Hydrochloride)
Activators & Inhibitors
Chemical Modulators

Verapamil (Hydrochloride) #49079

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Verapamil (Hydrochloride): Image 1
Chemical structure of Verapamil (Hydrochloride).

Product Usage Information

Verapamil (Hydrochloride) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.02 ml of water. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 491.1 g/mol
Purity >98%
Molecular Formula C27H38N2O4 • HCl
CAS 152-11-4
Solubility Soluble in water at 25 mg/ml.

Background

Verapamil (Hydrochloride) is a phenylalkylamine racemic mixture that inhibits the influx of extracellular calcium ions into myocardial and vascular smooth muscle cells by blocking L-type calcium channels and is commonly used in the treatment of high blood pressure, angina, and heart arrhythmias (1). Research has shown that Ca2+ channel blockers, such as Verapamil (Hydrochloride), can mediate Influenza A viral entry into cells (2). Studies have also shown Verapamil (Hydrochloride) to be an inhibitor of drug efflux pump proteins, such as P-glycoprotein, resulting in the reversal of multidrug resistance by tumor cells (3). As an L-type calcium channel antagonist, Verapamil (Hydrochloride) effectively inhibits Ebolaviruses (EBOV) infection with an IC50 value of 4 μM (4).
  1. Singh, B.N. (1986) Br J Clin Pharmacol 21 Suppl 2, 109S-121S.
  2. Nugent, K.M. and Shanley, J.D. (1984) Arch Virol 81, 163-70.
  3. Naito, M. and Tsuruo, T. (1989) Cancer Res 49, 1452-5.
  4. Sakurai, Y. et al. (2015) Science 347, 995-8.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 49079
Cat. # Size Qty. Price
49079S
1 g $ 75