GPNMB Antibodies

Target Information

Could be a melanogenic enzyme. Belongs to the PMEL/NMB family. Widely expressed, but very low expression, if any, in the brain (PubMed:12609765, PubMed:16609006). Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level) (PubMed:29336782). Expressed in peripheral blood, but not bone marrow mononuclear cells (PubMed:12609765). Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level) (PubMed:16489096). May be overexpressed in various cancers, including melanoma and glioblastoma multiforme (PubMed:7814155, PubMed:16489096, PubMed:16609006). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

DC-H; DC-HIL; Dch; Dchil; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; Dendritic cell-associated transmembrane protein; glycoprotein (transmembrane) nmb; glycoprotein NMB; glycoprotein nmb-like protein; glycoprotein nonmetastatic melanoma protein B; GPNMB; Gpnmb; Hematopoietic growth factor inducible neurokinin-1 type; HGFIN; Hgfin; ipd; iris pigment dispersion; NMB; Nmb; osteoactivin; PLCA3; Transmembrane glycoprotein HGFIN; Transmembrane glycoprotein NMB