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β-Catenin (L54E2) Mouse mAb (Biotinylated) #5265
This product is discontinued
Gallery: β-Catenin (L54E2) Mouse mAb (Biotinylated) #5265
β-Catenin (L54E2) Mouse mAb (Biotinylated) detects endogenous levels of total β-catenin protein.Species predicted to react based on 100% sequence homology: Mouse, Rat, Pig
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human β-catenin protein.
This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The unconjugated β-Catenin (L54E2) Mouse mAb (IF Preferred) #2677 reacts with human β-catenin protein.
β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.