|13547S||1 Kit (500 assays)||
|Product Includes||Quantity (with Count)|
|0.1 M Nitrite Standard||1 x 1 ml|
|Reagent A: Sulfanilamide Solution||1 x 25 ml|
|Reagent B (NED Solution)||1 x 25 ml|
posted June 2020
Protocol Id: 2052
All Species Expected
Nitric Oxide (NO) is a pleiotropic signaling molecule that plays key roles in multiple cells types and tissues. NO is generated by three distinct nitric oxide synthase (NOS) enzymes that catalyze the oxidation of L-arginine into L-citrulline and NO (1). Two of these enzymes, endothelial NOS (eNOS) and neuronal NOS (nNOS), are constitutively expressed in many cell types (1). Inducible NOS (iNOS) is transcriptionally regulated and is expressed in response to inflammatory stimuli, such as pro-inflammatory cytokines (1). NO functions as a potent vasodilator and neurotransmitter (1). In the context of cancer, NO may function as either a tumor suppressor or tumor promoter (2). High levels of NO produced by macrophages are cytotoxic (2). In contrast, research studies have shown that lower levels of NO may contribute to tumorigenesis through promoting angiogenesis (2).
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