19.3
#O15520
2255
Background
FGF-10 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-10 functions as a signaling molecule that is involved in many important processes (1,2). It binds to receptor FGFR2b and is essential as a signaling growth factor for mesenchymal-to-epithelial transition (3). FGF-10 is involved in limb development and morphogenesis of multiple organs, such as lung, skin, ear, and salivary gland (3,4). Knockout mice for FGF-10 show severe phenotypes with complete truncation of the fore- and hindlimbs and they die shortly after birth due to impaired lung development (4).
Endotoxin
Endotoxin levels are less than or equal to 1 EU / 1 μg hFGF-10.
Purity
A greater than or equal to 95% purity was determined by SDS-PAGE.
Source / Purification
Recombinant human FGF-10 was expressed in E. coli and is supplied in a lyophilized form.
Bioactivity
The bioactivity of recombinant hFGF-10 was determined in a 4MBr-5 cell proliferation assay. The ED50 of each lot is less than or equal to 200 ng/mL.
Background
FGF-10 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-10 functions as a signaling molecule that is involved in many important processes (1,2). It binds to receptor FGFR2b and is essential as a signaling growth factor for mesenchymal-to-epithelial transition (3). FGF-10 is involved in limb development and morphogenesis of multiple organs, such as lung, skin, ear, and salivary gland (3,4). Knockout mice for FGF-10 show severe phenotypes with complete truncation of the fore- and hindlimbs and they die shortly after birth due to impaired lung development (4).
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
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